Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts 261
ORIGINAL ARTICLE
Year : 2018  |  Volume : 9  |  Issue : 2  |  Page : 58-62

How should we evaluate the patients with elevated 1 h-plasma glucose?


Department of Endocrinology and Metabolism, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People's Republic of Korea

Correspondence Address:
Dr. Ri-Hyang Paek
Pyongyang Medical College, Kim Il Sung University, Pyongyang
Democratic People's Republic of Korea
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjmsr.mjmsr_25_18

Rights and Permissions

Objectives: This study evaluated the cutoff values of 1 h-plasma glucose (1 h-PG) for the diagnosis of diabetes mellitus and impaired glucose tolerance (IGT), and demonstrated how to evaluate the patients with elevated 1 h-PG. Subjects and Methods: All patients (n = 1433) without known impaired glucose homeostasis (diabetes mellitus [DM] or prediabetes) that have been submitted to the Hospital of the Pyongyang Medical College Kim Il Sung University were enrolled in this study for evaluation of their glucose homeostasis. Results: The area under the receiver operating characteristic of 1 h-PG during 75 g oral glucose tolerance test for diagnosis of DM and IGT were 0.944 ± 0.020 (95% confidence interval [CI]: 0.906–0.983) and 0.964 ± 0.009 (95% CI: 0.944–0.984), respectively. The most optimal cutoff value of 1 h-PG for DM and IGT were 231.0 mg/dL and 161 mg/dL, respectively About 10.4% of normal glucose tolerance (NGT) subjects diagnosed by the present American Diabetes Association (ADA) criteria had 1 h-PG equal to 161 mg/dL or above, their insulin secretion level of pancreas was as low as IGT patient, insulin resistance was higher than NGT subjects with 1 h-PG <161 mg/dL. Moreover, 29.6% of “IGT” patients diagnosed by the present ADA criteria had 1 h-PG equal to 231 mg/dL or above, their insulin secretion level of pancreas was as low as DM patients, insulin resistance was lower than DM and similar to IGT patients with 1 h-PG <231 mg/dL. Conclusions: The cutoff value of 1 h-PG for DM and IGT is 231 mg/dL and 161 mg/dL, it has high sensitivity and specificity for the diagnosis of DM and IGT. The patients with elevated 1 h-PG should be considered as impaired glucose homeostasis (IGT or DM), and therefore treated in time.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed102    
    Printed7    
    Emailed0    
    PDF Downloaded21    
    Comments [Add]    

Recommend this journal