Muller Journal of Medical Sciences and Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 2  |  Page : 51--57

Safety and efficacy of low-dose transarterial chemoembolization in the hepatocellular carcinoma patients with portal vein tumor thrombosis


Won-Gyom Choe, Yong-Gun Jo, Il-Jin Sim, Guk-Song Kim, Guang-Jin Chon, U-Il Song, Yong-Jin Pong 
 Department of Oncology, Clinical Institute, Pyongyang Medical College, Kim Il Sung University, Pyongyang, North Korea

Correspondence Address:
Dr. Won-Gyom Choe
Clinical Institute, Pyongyang Medical College, Kim Il Sung University, Taesong District, Pyongyang
North Korea

Aim: The aim of the study is to analyze the safety and efficacy of low-dose transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT). Materials and Methods: Seventy-five HCC patients with PVTT, who were admitted to our hospital between 2011 and 2015 and underwent TACE, were analyzed. The safety and efficacy of low-dose TACE were evaluated. Results: The objective tumor response rate was 25.3%. The median overall survival time was 10.7 months (95% confidence interval [CI]: 8.2–13.2). The cumulative survival rates at 6, 12, 18, and 24 months were 65.3%, 44%, 17.3%, and 2.6%, respectively. Univariate analysis revealed that alpha-fetoprotein (heart rate [HR] = 1.307, 95% CI: 1.019–1.427,P < 0.05), Child–Pugh classification (HR = 2.984, 95% CI: 1.741–5.115, P < 0.001), PVTT (HR = 3.409, 95% CI: 2.745–4.512, P < 0.001), number of tumor (HR = 2.358, 95% CI: 1.956–3.375, P < 0.001), and size of tumor (HR = 2.301, 95% CI: 1.667–3.268, P < 0.001) were related with survival. In multivariate analysis, Child–Pugh classification (HR = 2.351, 95% CI: 1.256–4.215, P < 0.001), type of PVTT (HR = 2.749, 95% CI: 2.238–3.961, P < 0.001), number of tumor (HR = 1.795, 95% CI: 1.521–3.046, P < 0.001), and size of tumor (HR = 1.917, 95% CI: 1.379–3.057, P = 0.03) were independent predictive factors for survival rates. The incidence of complications due to procedures was 85.3%. Conclusion: The low-dose TACE may be considered selectively to HCC patients with PVTT. Child–Pugh classification, type of PVTT, number of tumor, and size of tumor were checked accurately before operation.


How to cite this article:
Choe WG, Jo YG, Sim IJ, Kim GS, Chon GJ, Song UI, Pong YJ. Safety and efficacy of low-dose transarterial chemoembolization in the hepatocellular carcinoma patients with portal vein tumor thrombosis.Muller J Med Sci Res 2018;9:51-57


How to cite this URL:
Choe WG, Jo YG, Sim IJ, Kim GS, Chon GJ, Song UI, Pong YJ. Safety and efficacy of low-dose transarterial chemoembolization in the hepatocellular carcinoma patients with portal vein tumor thrombosis. Muller J Med Sci Res [serial online] 2018 [cited 2019 Jun 17 ];9:51-57
Available from: http://www.mjmsr.net/article.asp?issn=0975-9727;year=2018;volume=9;issue=2;spage=51;epage=57;aulast=Choe;type=0