Muller Journal of Medical Sciences and Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 2  |  Page : 58--62

How should we evaluate the patients with elevated 1 h-plasma glucose?


Ri-Hyang Paek, Hak-Chol Ri, Chol-Min Pae 
 Department of Endocrinology and Metabolism, Pyongyang Medical College, Kim Il Sung University, Pyongyang, Democratic People's Republic of Korea

Correspondence Address:
Dr. Ri-Hyang Paek
Pyongyang Medical College, Kim Il Sung University, Pyongyang
Democratic People's Republic of Korea

Objectives: This study evaluated the cutoff values of 1 h-plasma glucose (1 h-PG) for the diagnosis of diabetes mellitus and impaired glucose tolerance (IGT), and demonstrated how to evaluate the patients with elevated 1 h-PG. Subjects and Methods: All patients (n = 1433) without known impaired glucose homeostasis (diabetes mellitus [DM] or prediabetes) that have been submitted to the Hospital of the Pyongyang Medical College Kim Il Sung University were enrolled in this study for evaluation of their glucose homeostasis. Results: The area under the receiver operating characteristic of 1 h-PG during 75 g oral glucose tolerance test for diagnosis of DM and IGT were 0.944 ± 0.020 (95% confidence interval [CI]: 0.906–0.983) and 0.964 ± 0.009 (95% CI: 0.944–0.984), respectively. The most optimal cutoff value of 1 h-PG for DM and IGT were 231.0 mg/dL and 161 mg/dL, respectively About 10.4% of normal glucose tolerance (NGT) subjects diagnosed by the present American Diabetes Association (ADA) criteria had 1 h-PG equal to 161 mg/dL or above, their insulin secretion level of pancreas was as low as IGT patient, insulin resistance was higher than NGT subjects with 1 h-PG <161 mg/dL. Moreover, 29.6% of “IGT” patients diagnosed by the present ADA criteria had 1 h-PG equal to 231 mg/dL or above, their insulin secretion level of pancreas was as low as DM patients, insulin resistance was lower than DM and similar to IGT patients with 1 h-PG <231 mg/dL. Conclusions: The cutoff value of 1 h-PG for DM and IGT is 231 mg/dL and 161 mg/dL, it has high sensitivity and specificity for the diagnosis of DM and IGT. The patients with elevated 1 h-PG should be considered as impaired glucose homeostasis (IGT or DM), and therefore treated in time.


How to cite this article:
Paek RH, Ri HC, Pae CM. How should we evaluate the patients with elevated 1 h-plasma glucose?.Muller J Med Sci Res 2018;9:58-62


How to cite this URL:
Paek RH, Ri HC, Pae CM. How should we evaluate the patients with elevated 1 h-plasma glucose?. Muller J Med Sci Res [serial online] 2018 [cited 2019 Feb 19 ];9:58-62
Available from: http://www.mjmsr.net/article.asp?issn=0975-9727;year=2018;volume=9;issue=2;spage=58;epage=62;aulast=Paek;type=0