Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts 80


 
 Table of Contents  
LETTER TO EDITOR
Year : 2014  |  Volume : 5  |  Issue : 1  |  Page : 91

Tuberous sclerosis complex


Department of Dermatology, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India

Date of Web Publication15-Mar-2014

Correspondence Address:
Namitha Chathra
Department of Dermatology, Father Muller Medical College, Kankanady, Mangalore - 575 002, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0975-9727.128969

Rights and Permissions
How to cite this article:
Chathra N, Bhat M R. Tuberous sclerosis complex. Muller J Med Sci Res 2014;5:91

How to cite this URL:
Chathra N, Bhat M R. Tuberous sclerosis complex. Muller J Med Sci Res [serial online] 2014 [cited 2021 Oct 25];5:91. Available from: https://www.mjmsr.net/text.asp?2014/5/1/91/128969

Dear Editor,

A 28-year-old male with insignificant family history presented with asymptomatic reddish raised lesions on the face and neck, which were first noticed by him when he was 8 years old. There is no history suggestive of systemic involvement or progression of the lesions. On examination, several reddish-brown papules of varying sizes were noted [Figure 1]a which were confirmed as angiofibromas with the aid of histology. He was also found to have multiple randomly distributed dental enamel pits [Figure 2]a. With a diagnosis of tuberous sclerosis in mind, he was evaluated further. Fundus examination revealed left astrocytoma [Figure 2]b, computed tomography scan of the brain showed a few calcified subependymal nodules [Figure 2]c, ultrasonography abdomen was suggestive of adrenal lipoma [Figure 2]d and echocardiogram did not detect any abnormality. A definite diagnosis of tuberous sclerosis was made based on the presence of two major features. [1] The skin lesions were ablated using carbon dioxide laser [Figure 1]b but patient refused further evaluation and management of systemic lesions.
Figure 1: (a) Multiple angiofibromas on the face. (b) Post ablation with CO2 laser

Click here to view
Figure 2: (a) Multiple randomly distributed dental enamel pits. (b) Fundus examination-left astrocytoma. (c) Computed tomography scan of the braincalcified subependymal nodules. (d) Ultrasonography abdomen-adrenal lipoma

Click here to view


Tuberous sclerosis complex is an autosomal dominant multisystem hamartomatosis involving mainly the skin, eye, central nervous system, heart, lungs, kidneys and bones. The incidence is as high as 1 in 6000 live births and the affected individuals exhibit decreased overall survival in comparison with the general population, although some may have a normal life span with few medical complications. [2]

 
  References Top

1.Roach ES, Gomez MR, Northrup H. Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria. J Child Neurol 1998;13:624-8.  Back to cited text no. 1
    
2.Osborne JP, Fryer A, Webb D. Epidemiology of tuberous sclerosis. Ann N Y Acad Sci 1991;615:125-7.  Back to cited text no. 2
    


    Figures

  [Figure 1], [Figure 2]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
References
Article Figures

 Article Access Statistics
    Viewed2202    
    Printed61    
    Emailed0    
    PDF Downloaded225    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]