Muller Journal of Medical Sciences and Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 4  |  Issue : 2  |  Page : 74--77

A hospital-based study of anti-TPO titer in patients with thyroid disease


E Jacob Jeena1, M Malathi1, K Sudeep2 
1 Department of Biochemistry, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India
2 Department of Endocrinology, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India

Correspondence Address:
M Malathi
Department of Biochemistry, Father Muller Medical College, Kankanady, Mangalore - 575 002, Karnataka
India

Context: Autoimmunity against the thyroid gland is one of the most important causes for thyroid dysfunction. Anti-thyroid antibody test is an important tool in the evaluation of autoimmune thyroid disorders. Aims: To study the prevalence of thyroid hormone dysfunction and positive anti-TPO antibody titers in patients being evaluated for thyroid-related disorders. Settings and Design:This retrospective cross-sectional study was done in Father Muller Medical College. Materials and Methods: The TSH (Thyroid stimulating hormone), FT 4 (Free thyroxine), and anti-TPO titer reports of 74 subjects undergoing evaluation for thyroid-related disorders were analyzed. Statistical Analysis Used: Statistical significance was estimated by P value. Results: About two-third (60%) of hypothyroid patients showed raised TPO antibody titer. The titer was significantly higher in hypothyroid subjects when compared to the euthyroid subjects, and a majority of the hypothyroid subjects had a titer at least twice the upper limit of normal. Two of the three subjects with hyperthyroidism also had elevated anti-TPO titers. Conclusions: The commonest cause of hypothyroidism in our study subjects was autoimmune-related thyroid disease. Anti-TPO antibody estimation is a very useful test for establishing the etiological diagnosis of autoimmune thyroid diseases in our population. In situations where there is a diffuse non-progressive goiter, anti-TPO antibody estimation can substitute for an invasive FNAC.


How to cite this article:
Jeena E J, Malathi M, Sudeep K. A hospital-based study of anti-TPO titer in patients with thyroid disease.Muller J Med Sci Res 2013;4:74-77


How to cite this URL:
Jeena E J, Malathi M, Sudeep K. A hospital-based study of anti-TPO titer in patients with thyroid disease. Muller J Med Sci Res [serial online] 2013 [cited 2020 Nov 29 ];4:74-77
Available from: https://www.mjmsr.net/article.asp?issn=0975-9727;year=2013;volume=4;issue=2;spage=74;epage=77;aulast=Jeena;type=0