Muller Journal of Medical Sciences and Research

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 6  |  Issue : 2  |  Page : 107--111

Histopathological profile of ovarian tumours: A twelve year institutional experience


Deepti Vijay Mankar, Gaurav K Jain 
 Department of Pathology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India

Correspondence Address:
Dr. Deepti Vijay Mankar
Department of Pathology, 2nd Floor, Krishna Institute of Medical Sciences, Malkapur, Karad - 415 110, District - Satara, Maharashtra
India

Abstract

Context: Ovarian tumours represent about 30% of all cancers of the female genital system. They manifest in a wide spectrum of clinical, morphological and histological features. Aim: To study the frequency of incidence of different histopathological types of ovarian tumours in our institute. Materials and Methods: This retrospective study included 257 cases of histopathologically proven ovarian tumours, reported in the Department of Pathology of a rural tertiary care referral hospital, over a 12 year period (January 2000 to December 2011). These were classified according to the WHO classification of ovarian tumours (2003). Clinical presentation of the patients was analysed from archived case records. Results: Of the 257 tumours studied, 162 (63.04%) were benign, 15 (5.84%) were borderline and 80 (31.12%) were malignant. Surface epithelial tumours were the most common (68.48%) followed by germ cell tumours (15.95%). Mucinous cystadenomas (32.69%) were the most common benign tumours, while serous cystadenocarcinomas (31.13%) were the most common malignant tumours. Most ovarian neoplasms (43.19%) occurred in the 21-40 years age-group. Dull abdominal pain was the most common clinical presentation. Conclusions: Benign ovarian tumours were more common than malignant ones across all age groups. Surface epithelial tumours were the most common histopathological type of ovarian tumour. Due to vague symptoms, patients present late. Development of methods for early diagnosis of ovarian neoplasia is therefore, a pressing need today. The relative frequency of incidence of different ovarian tumours shows regional variations, highlighting the need to identify region-specific risk factors.



How to cite this article:
Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience.Muller J Med Sci Res 2015;6:107-111


How to cite this URL:
Mankar DV, Jain GK. Histopathological profile of ovarian tumours: A twelve year institutional experience. Muller J Med Sci Res [serial online] 2015 [cited 2021 Jan 20 ];6:107-111
Available from: https://www.mjmsr.net/text.asp?2015/6/2/107/160675


Full Text

 Introduction



Ovarian tumours represent about 30% of all cancers of the female genital system. [1] Indian trend analysis reveal a steady increase in the age-standardized incidence rate of ovarian cancer, ranging from 0.26% to 2.44% per year in different area registries. [2] Conversely, incidence and mortality rates due to ovarian cancer have shown a slight decline over the last few decades in countries like Denmark. [3] Recent improvement in patient survival in developed countries is attributed to an earlier stage at diagnosis. [4] Ovarian tumours are often difficult to detect until they are advanced in stage or size, as symptoms are vague and insidious. Identification of various histologic patterns of ovarian tumours is important for diagnosis as well as prognosis. This study was conducted with the aim of finding out the frequency of incidence of different histologic types of ovarian tumours reported by the Department of Pathology of a rural tertiary care referral hospital.

 Materials and Methods



This retrospective study included 257 consecutive cases of histopathologically proven ovarian tumours, reported by the Department of Pathology of our institute, over a 12 year period (January 2000 to December 2011). All non-neoplastic or tumour-like lesions of the ovary were excluded.

Paraffin blocks of the ovarian tumours were retrieved, 3-5 micron thick sections prepared, stained with H&E and studied subsequently. The WHO classification of ovarian tumours (2003) was used for classifying the tumours. [5] The clinical presentation of the patients was analysed from their archived case records. All required data was retrieved from the archived records of the hospital.

 Results



From January 2000 to December 2011, a total of 257 neoplastic ovarian specimens were received in the Department of Pathology of our institute. These specimens were removed from 227 patients, 30 (11.67%) of whom had synchronous bilateral ovarian malignancies.

Out of these, 63.04% (162/257) were benign, 5.84% (15/257) were borderline and 31.12% (80/257) were malignant. Surface epithelial tumours were the most common (68.48%), followed by germ cell tumours (15.95%).

Surface epithelial tumours comprised 69.75% (113/162) of all benign tumours, 60.00% (48/80) of all malignant tumours. They were the most common benign and borderline tumours across all age groups, while germ cell tumours were the most common malignant tumours up to 20 years of age. The youngest patient in this series was a 14 year old girl with a malignant teratoma. Most germ cell tumours, both benign and malignant, were seen in women younger than 40 years. Most sex-cord stromal tumours (83.34%) occurred in women above 40 years of age. Our oldest patient was a 76 year old lady, diagnosed with a benign thecoma. Malignant tumours were most common between 41-60 years [Table 1]. {Table 1}

The most common clinical presentation (33.48%) was a complaint of vague pain in abdomen, which was often of the dull or dragging type. Occasional tumours, commonly of the benign type, presented with severe, acute onset abdominal pain, consequent to twisting of the ovarian pedicle. Most women reported symptoms for a period over 6-12 months, which often progressed gradually. A significant proportion of cases (14.98%) were asymptomatic at presentation and were only incidentally diagnosed [Table 2].{Table 2}

Among benign surface epithelial tumours, mucinous cystadenomas [Figure 1] were the most common, while both mucinous and serous borderline tumours had nearly equal incidence. Among malignant surface epithelial tumours, serous cystadenocarcinomas [Figure 2], [Figure 3] outnumbered all others.{Figure 1}{Figure 2}{Figure 3}

Germ cell tumours were the second (41/257) most common tumours observed in this study, a majority i.e. 80.49% (33/41) of which were benign mature cystic teratomas [Figure 4], [Figure 5].{Figure 4}{Figure 5}

Sex cord stromal tumours comprised 9.34% (24/257), the third most common category observed. Fibromas [Figure 6] were the most common benign sex cord stromal tumours, granulosa cell tumours [Figure 7] being the most common malignant type.{Figure 6}{Figure 7}

Metastatic ovarian neoplasms were seen in 10 patients, 6 of whom had bilateral metastasis, yielding a total of 16 out of 257 specimens. Two of these were cases of Krukenberg tumour [Figure 8] metastatic from gastric adenocarcinomas; while, colonic adenocarcinoma (6), endometrial carcinoma (1) and renal cell carcinoma [Figure 9] (1) were the primary malignancies in the rest.{Figure 8}{Figure 9}

 Discussion



In the present study, 63.04% tumours were benign, 5.84% were borderline and 31.12% were malignant. Compared to studies in western countries, where 75-80% of tumours were benign, [1] this study shows a relative decrease in the percentage of benign tumours and a consequent increase in the percentage of malignant tumours, which agreed with the findings of Ahmad et al., who reported an incidence of 59.18%, 0.2% and 40.81% for benign, borderline and malignant tumours respectively. [6] Pilli et al., [7] and Gupta et al., [8] however, reported figures of 75.2%, 2.8%, 21.9% and 72.9%, 4.10%, 22.9% for benign, borderline and malignant ovarian tumours respectively.

Histopathologically, surface epithelial tumours (68.48%) were the most common category of ovarian tumours encountered, followed by germ cell tumours. This agrees with the findings of Gupta et al. and others. [8],[9],[10] Surface epithelial tumours account for 50.0-55.0% of all ovarian tumours and their malignant forms for approximately 90.0% of all ovarian cancers in the western world. Corresponding figures for Japan are 46.0-50.0% and 70-75% respectively. [1] Malignant surface epithelial tumours account for only 60.00% of all ovarian malignancies in our series. This corresponds with the findings of Ahmed et al. and Jha et al., who reported incidences of 63.5% and 69.2% respectively for surface epithelial malignancies. [6],[11]

Among benign surface epithelial tumours, mucinous cystadenomas were the most common. Here, we differ from the findings of Shah et al. and Thanikasalam et al., each of whom reported that serous cystadenomas were the most common benign ovarian tumours. [9],[12]

Among borderline surface epithelial tumours, both mucinous and serous types had nearly equal incidence in our study. However, Li et al. noted an incidence of 38% and 51% for serous and mucinous borderline tumours respectively. [13] Also discordant, were the findings of Priya et al., who observed that serous borderline tumours were commoner than mucinous borderline tumours. [14]

Among the malignant tumours, serous cystadenocarcinomas (31/80-38.75%) outnumbered all others in our series. This agreed with the findings (46.2%) of Jha et al. [11] However, Swamy et al. having recorded granulosa cell tumours, and Yasmin et al. observing endometroid carcinomas as the most common ovarian malignancies respectively, differed. [15],[16]

Relative frequencies of incidence of different ovarian tumours are different for western and Asian countries. [5],[17],[18] The data available from this study can help in recognizing the pattern of ovarian tumours prevalent in this part of the world.

A majority of the tumours diagnosed in our study occurred in the 21-40 years age-group [Chart 1]. This agreed with the findings of studies by Pilli et al., Shah et al. and Jha et al. [7],[9],[11][INLINE:1]

Most (52/80, 65%) malignant tumours were diagnosed in women above 40 years of age. Yet, a significant proportion (35%) of ovarian malignancies was found in women younger than 40 years [Chart 1]. This agreed with the findings of Jha et al., who found 26.90% of malignant neoplasms in women up to 40 years of age. [11]

The highest number of malignant tumours (40/80) was diagnosed in the 41-60 years age group [Chart 1]. Basic et al. found ovarian cancers occurred most frequently in a similar age group, but they reported no ovarian cancers below 40 years of age. [19] Shah et al. and Wasim et al. also found ovarian cancers unusual before age 40. [9],[20]

This study, as well as others from neighbouring countries, which are included here for comparison, have a relatively small sample size, whereas most of the data of the western world is the result of large population-based studies. This could be one cause of variation in results.

Alarmingly, we have observed an increased incidence of ovarian malignancy in our study, which calls for more research into region-specific risk factors. A more complete understanding of the epidemiologic and genetic determinants of ovarian cancer may lead to the development of better screening and detection methods for this disease.

 Conclusions



Benign ovarian tumours were more common than malignant ones across all age groups. On morphological grounds, tumours originating from surface epithelium were the most common variant. Though a majority of the tumours were benign, a higher incidence of malignancy was observed in our study as compared to those by other authors, which is an alarming finding. Vague, insidious-onset, dull pain in abdomen was the most common clinical presentation. As most of the malignant ovarian tumours present late, development of methods for early diagnosis is a pressing need today. The relative frequency of incidence of ovarian tumours is known to be different for western and Asian countries; we have additionally observed intra-regional variations in incidence rates within Asia. It is, therefore, suggested that further efforts must be made to identify region-specific risk factors for ovarian oncogenesis.

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